β-Functionalization of carboxylic anhydrides with β-alkyl substituents through carbene organocatalysis.
نویسندگان
چکیده
The first NHC-catalyzed functionalization of carboxylic anhydrides is described. In this reaction, the β carbon behaves as a nucleophilic carbon and undergoes asymmetric reactions with electrophiles. Anhydrides with challenging β-alkyl substituents work effectively.
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 53 49 شماره
صفحات -
تاریخ انتشار 2014